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Exenatide does not slow Parkinson’s disease progression compared to placebo
1. There was no significant difference in functional outcome between both groups at 96 weeks. 2. Exenatide was safe and...
The Classics
Physician-written reports of landmark studies in medicine
Triptans may be the most effective treatments available for acute episodic migraine
1. In this systematic review and meta-analysis, the combination of triptans and non-steroidal anti-inflammatory drugs (NSAIDs) was the most effective...
AAV9.LAMP2B gene therapy shows clinical benefit in Danon disease
1. In seven patients with Danon disease, a single infusion of adeno-associated virus serotype 9 carrying transgene LAMP2B (AVV9.LAMP2B) therapy...
Coronary CT-angiography-guided management improves outcomes in patients with stable chest pain
1. Composite of coronary heart disease death and non-fatal myocardial infarction was less frequent in the CCTA group compared to...
Adjunctive middle meningeal artery embolization superior to standard care in symptomatic chronic subdural hematomas
1. In this randomized controlled trial, middle meningeal artery embolization demonstrated a decreased risk of treatment failure in patients with...
Abelacimab reduces bleeding risk compared to rivaroxaban in atrial fibrillation
1. In this randomized controlled trial, abelacimab led to significantly lower rates of major or clinically relevant nonmajor bleeding compared...
Intraosseous and intravenous vascular access are equally effective for ROSC following out-of-hospital cardiac arrest
1. In this randomized clinical trial, among patients who had an out-of-hospital cardiac arrest, no significant difference was found in...
Intraosseous drug administration does not improve survival in out of hospital cardiac arrest
1. In this randomized trial, intraosseous-first vascular access did not result in higher 30-day survival than intravenous-first strategies in adults...
Transcatheter tricuspid-valve replacement provides mortality and quality of life benefits
1. In this randomized controlled trial, a transcatheter tricuspid-valve replacement provided a mortality benefit compared to standard medical therapy after...
Cabozantinib significantly improves progression free survival in patients with advanced neuroendocrine tumors
1. In this randomized controlled trial, cabozantinib significantly improved progression-free survival in patients with progressive pancreatic and extra-pancreatic neuroendocrine tumors....