General Medicine Classics

Physician-written reports of landmark medical studies

The Child-Pugh score: Prognosis in chronic liver disease and cirrhosis [Classics Series]

1. The Child-Pugh score consists of five clinical features and is used to assess the prognosis of chronic liver disease and cirrhosis. 2. The Child-Pugh...
Classics Series, Landmark Trials in Medicine

The CLOT trial: Dalteparin versus warfarin [Classics Series]

This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series). 1....
Classics Series, Landmark Trials in Medicine

The NICE-SUGAR trial: Intensive glycemic control harmful in the ICU [Classics Series]

1. Intensive glycemic control in critically ill patients significantly increases 90-day mortality when compared to conventional glycemic control. 2. The incidence of severe hypoglycemia was...
Classics Series, Landmark Trials in Medicine

The POISE trial: Perioperative use of beta-blockers [Classics Series]

1. The POISE trial was a randomized controlled trial exploring the effect of perioperative beta-blockers on cardiac death, nonfatal myocardial infarctions, and nonfatal cardiac...
Classics Series, Landmark Trials in Medicine

The RE-LY trial: Dabigatran non-inferior to warfarin in preventing strokes in patients with atrial...

Image: CC/L. academia 1. High-dose dabigatran is superior to warfarin in the prevention of strokes in patients with atrial fibrillation, while low-dose dabigatran is non-inferior...
Classics Series, Landmark Trials in Medicine

The RALES trial: Spironolactone decreases all-cause mortality in heart failure patients [Classics Series]

Image: PD 1. Adding 25 mg of spironolactone to standard therapy reduces all-cause mortality in heart failure patients with an ejection fraction <35% Original Date of...
Classics Series, Landmark Trials in Medicine

The Wells DVT criteria: Clinical prediction model for deep vein thrombosis [Classics Series]

1. The Wells DVT criteria are a validated clinical model for estimating pre-test probability of DVT. 2. D-dimer testing in outpatients can help inform the...
Classics Series, Landmark Trials in Medicine

The ARISTOTLE trial: Apixaban vs warfarin in atrial fibrillation [Classics Series]

Image: PD 1. Apixiban is superior to warfarin in preventing stroke in patients with atrial fibrillation 2. Apixaban has a decreased risk of intracranial hemorrhage compared...
Classics Series, Landmark Trials in Medicine

The COURAGE trial: PCI does not improve mortality in medically optimized patients with stable...

Image: PD 1. Addition of percutaneous cutaneous intervention (PCI) to optimal medical therapy for patients with stable coronary artery disease does not improve mortality or...
Classics Series, Landmark Trials in Medicine

The SPARCL trial: Atorvastatin reduces risk of stroke in patients with recent stroke or...

Image: CC/L. academia 1. In patients with recent stroke or TIA, high-dose atorvastatin significantly reduces the risk of fatal stroke compared to placebo 2. Atorvastatin was also...
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