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✦EvidencePulse™by 2 Minute Medicine3 reportsYou askedtop stroke trials 2026Synthesizing medical evidence...Top 2026 stroke trial results:OCEANIC — ischemic stroke: 6.2% vs 8.4%OPTION* — mRS 0–1: 43.6% vs 34.2%ORIENTAL* — mRS 0–2: 58.6% vs 46.6%*Higher sICH in intervention armsParticipants randomizedNOCEANIC12,327OPTION570ORIENTAL564Ask about guidelines or landmark trials...↑Try EvidencePulse™Ask the evidence. Get the signal.Try it now →
Home Wellness

Higher step counts may result in lower risk of adverse outcomes

byNicholas Ng Fat HingandAvneesh Bhangu
March 7, 2022
in Wellness
Reading Time: 2 mins read
Walking for health collage: a pair of walking shoes and a fitness band at the start of a winding path toward a tree
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1. A nonlinear dose-response association was observed between step count and all cause death and cardiovascular disease.

2. A 1000 step increment of steps per day was associated with a 23% decreased risk of all-cause mortality. For every 500 steps increased per day, the risk of cardiovascular disease was 6% lower.

Evidence Rating Level: 1 (Excellent)

Walking is a well-known sustainable form of physical activity that can be performed anywhere. Society has touted a goal of 10,000 steps per day as being ideal for health but there is little evidence to support this claim. Most studies associated with walking and life expectancy use self-declared indicators of daily steps and walking time and are therefore inadequate. As a result, the present meta-analysis sought to study the dose-response relationship between step count and all-cause mortality and cardiovascular disease.

Of 9673 identified studies, 16 were included from database inception to July 2021. Studies were included if they had a prospective design or a clinical trial and evaluated the influence of daily step count on at least one outcome of: all-cause mortality or cardiovascular disease (death, coronary heart disease or stroke). Studies were excluded if participants were not recruited from the general population in good health. Quality assessment was done following the Newcastle-Ottawa Quality Assessment scale.

Results demonstrated a nonlinear dose-response association between step count and all cause death and cardiovascular disease. Furthermore, a 1,000 step increment of steps per day was associated with a 23% decreased risk of all-cause mortality. For every 500 steps increased per day, the risk of cardiovascular disease was 6% lower. However, the present study was limited by its generalizability due to a sample size comprised primarily of adults with higher socioeconomic status. Despite this, the quality of the results were high due to the measurement of step count by wearable devices and the inclusion of prospective designs/clinical trials. This study overall was significant in suggesting the value of walking on all-cause mortality and cardiovascular health.

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Tags: cardiovascular diseasedeathexercisewalkwellness
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✦ EvidencePulse™ by 2 Minute Medicine 3 reports You asked top stroke trials 2026 Synthesizing medical evidence... Top 2026 stroke trial results: OCEANIC — ischemic stroke: 6.2% vs 8.4% OPTION* — mRS 0–1: 43.6% vs 34.2% ORIENTAL* — mRS 0–2: 58.6% vs 46.6% *Higher sICH in intervention arms Participants randomizedN OCEANIC 12,327 OPTION 570 ORIENTAL 564 Ask about guidelines or landmark trials... Try EvidencePulse™ Get the signal. Try it now → Physician-trained medical AI by 2 Minute Medicine

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