• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Dolutegravir associated with improved viral suppression in HIV-positive pregnant patients

byAndrew LeeandKiera Liblik
September 5, 2022
in Chronic Disease, Infectious Disease, Obstetrics, Pediatrics, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Dolutegravir is associated with greater viral suppression at birth for human immunodeficiency virus (HIV)-positive pregnant patients compared to standard treatment regimens. 

2. There were no clear differences in adverse birth outcomes between patients on dolutegravir-based therapies compared to those who were not.

Evidence Rating Level: 1 (Excellent)

Study Rundown: HIV-positive pregnant patients require antiretroviral therapy (ART) to prevent pregnancy complications. The data on the effectiveness and safety of dolutegravir-based therapies have not been sufficient in the current literature. Participants who received dolutegravir had a higher percentage of pregnancies in which viral suppression was present compared to other types of ART. Of pregnancies where ART was started during pregnancy, dolutegravir had greater rates of viral suppression at delivery than those on other ART. The adverse outcomes of being born premature, having low birth weight, and being small for gestational age were not significantly different between groups on dolutegravir versus other forms of ART. No neonatal deaths occurred in any of the groups. Four instances of perinatal HIV transmission occurred, none of which were in participants taking dolutegravir. A strength of this study is the large and diverse population size from multiple countries and of various health statuses. A limitation of the study was that important predictors of adverse birth outcomes were not reported, such as parity, previous preterm birth, and pre-pregnancy body mass index. This study contributes important information on the effectiveness of dolutegravir specifically for HIV-positive pregnant patients.

Click to read the study in NEJM

In-Depth [prospective cohort]: The present study aimed to delineate the efficacy of dolutegravir as compared to other ARTs for HIV-positive pregnant patients. The study included 120 participants on dolutegravir, 464 on atazanavir-ritonavir, 185 on oral rilpivirine, 86 on raltegravir, and 159 on elvitegravir-cobicistat. A total of 51% of participants received ART before conception. Most pregnancies were in non-Hispanic Black participants, with a median age of conception of 29 years. Comparisons between dolutegravir and other ART regimens were adjusted for age of conception, the participant reported race and ethnic group, level of educational attainment, the timing of maternal HIV infection diagnosis, trimester at the first prenatal care visit, preconception or postconception use of ART, alcohol use during pregnancy, and any sexually transmitted infections during pregnancy. For those who received dolutegravir, 96.7% had viral suppression at delivery compared to 84% for atazanavir-ritonavir, 90.1% in darunavir-ritonavir, 89.2% in raltegravir, and 89.8% for elvitegravir-cobicistat. When compared to other forms of ART, dolutegravir had greater rates of viral suppression at delivery. Specifically, compared to atazanavir-ritonavir, dolutegravir had an adjusted risk difference of -13% (95% Confidence Interval, -17.0 to -6.1). For participants on dolutegravir or who received dolutegravir in the first trimester, three of 95 infants were born with major congenital anomalies. No clear differences were observed across all ART regimens and dolutegravir regarding other adverse birth outcomes. This study provides evidence for the effectiveness and safety of dolutegravir in HIV-positive pregnant patients.

Image: PD

RELATED REPORTS

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia

Chronic obstructive pulmonary disease associated with worse postoperative outcomes

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: atazanavirchronic diseasecobicistatdarunavirDolutegravirelvitegravirHIVhiv-positive pregnancyHIV/AIDShuman immunodeficiency virus (HIV)infectious diseaseneonatologyobstetricspediatricspregnancypublic healthraltegravirritonavirviral suppression
Previous Post

Incidence of C. difficile infections decreasing in hospitalized children

Next Post

Adjuvant erlotinib increased overall survival when compared to chemotherapy in stage IIIA EGFR-mutant non-small cell lung cancer

RelatedReports

β-blockers linked to improved survival in preserved ejection fraction heart failure
Cardiology

Catheter ablation reduces rates of persistent atrial fibrillation and atrial tachyarrhythmia

January 27, 2023
Brain lesions on MRI linked with subsequent increased stroke risk
Chronic Disease

Deep intronic FGF14 repeat expansion associated with late-onset cerebella ataxia

January 27, 2023
2 Minute Medicine Rewind May 20, 2019
Chronic Disease

Chronic obstructive pulmonary disease associated with worse postoperative outcomes

January 26, 2023
Fish oil and aspirin did not reduce arteriovenous fistula failure: The FAVOURED trail
Cardiology

Empagliflozin use is associated with slower progression of chronic kidney disease

January 26, 2023
Next Post
Patient Basics: Lung Cancer Overview

Adjuvant erlotinib increased overall survival when compared to chemotherapy in stage IIIA EGFR-mutant non-small cell lung cancer

Age and number of islet autoantibodies associated with diabetes risk

Sacituzumab govitecan may be an effective treatment for heavily pre-treated HR+/HER2- metastatic breast cancer.

Patient Basics: Heart Attack (Myocardial Infarction)

Ischemic events associated with greater mortality risk than bleeding events among adults with acute myocardial infarction on antithrombotic therapy

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Torsemide does not provide additional decrease in mortality compared to furosemide among patients hospitalized for heart failure
  • Community-based adult vision screening program increases access to eye care
  • Aspirin thromboprophylaxis noninferior to low-molecular-weight heparin in patients with fractures
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options