Tag: thrombolysis

1. Patients presenting between 4.5 and 9 hours after stroke onset with viable brain tissue who received thrombolytic therapy had better neurological outcomes compared to those receiving placebo. 2. Symptomatic intracranial hemorrhage occurred in a higher number of patients in the thrombolysis group compared to placebo group. Evidence Rating Level: 1...
1. Patients presenting between 4.5 and 9 hours after stroke onset with viable brain tissue who received thrombolytic therapy had better neurological outcomes compared to those receiving placebo. 2. Symptomatic intracranial hemorrhage occurred in a higher number of patients in the thrombolysis group compared to placebo group. Evidence Rating Level: 1...
Intravenous thrombolytic therapy with alteplase (recombinant human tissue plasminogen activator) is approved for the treatment of acute ischemic stroke. However, whether it is efficacious in the treatment of lacunar infarcts remains unclear. In this secondary post-hoc analysis of the WAKE-UP randomized controlled trial, 108 patients with acute lacunar stroke...
Outcomes of Extremely Preterm Infants With Birth Weight Less Than 400 g Little is known about the survival and neurodevelopmental outcomes of extremely preterm infants with low birth weight. More data is needed to facilitate decisions regarding the initiation of treatment and resuscitation in this population. In this retrospective cohort...
1. Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized to alteplase were more likely to have a favorable outcome at 90 days than those receiving placebo. 2. Rates of death and symptomatic intracranial hemorrhage were...
1. When treated with tenecteplase, stroke patients eligible for mechanical thrombectomy had higher rates of reperfusion and superior clinical outcomes at 90 days relative to patients treated with alteplase. 2. There was no evidence that rates of intracerebral hemorrhage were different between the tenecteplase and alteplase groups. Evidence Rating Level: 1...
1. Use of ticagrelor resulted in similar rates of major bleeding compared to clopidogrel in patients with ST elevation myocardial infarction treated with thrombolysis. Evidence Rating Level: 2 (Good) Study Rundown: Antiplatelet therapy is a major component of management of acute myocardial infarction. Ticagrelor results in greater and more rapid P2Y12...
1. Patients with proximal deep venous thrombosis (DVT) experience similar rates of post-thrombotic syndrome (PTS) when treated with pharmacomechanical catheter-directed thrombolysis (PCDT) plus anticoagulation versus anticoagulation alone. 2. Although treatment with PCDT and anticoagulation was associated with reduced severity of PTS compared to anticoagulation alone, no significant difference in quality...
1. When used for the selection of patients with stroke for intravenous thrombolysis within 3 hours of symptom onset, computed tomography perfusion imaging (CTP) appears to provide comparable outcomes relative to the use of other imaging modalities. 2. Outcomes trended toward superiority among patients selected for intravenous thrombolytic treatment beyond 3...
Image: PD  1. Ambulances equipped to give tissue plasminogen activator (tPA) for ischemic stroke allowed for more rapid treatment and increased rates of treatment.  2. Seven-day mortality in individuals given tPA on ambulances was no different when compared to those treated with tPA in the hospital.  Evidence Rating Level: 2 (Good)  Study Rundown:...